Why You’re Waking Up at 3AM (and What to Do About It)

You fall asleep just fine… but then suddenly you’re wide awake at 3:00 AM, staring at the ceiling. Sound familiar? If this happens often, your internal clock, or circadian rhythms, might be playing a bigger role than you think. Let’s break it down with an analogy. Your Sleep System is Like a Water Cooler Picture […]

Maximizing light is not the goal for health

Imagine it’s summer, and you live way up north. The sun is up for 22 hours of the day. Sunlight is good for sleep, right? Your sleep must be great. Except, no. It sucks. And the reason it sucks isn’t just because it’s hard to sleep when it’s bright outside (people in northern latitudes know […]

Circadian Amplitude to the Max

Let’s say I want to boost circadian amplitude as much as I can. What light/dark schedule should I put myself on?  This is a very tough question to answer experimentally, given how many possible light/dark schedules there are (infinite) and how expensive experiments like this can be (near infinite). But mathematical modeling can give us […]

Measuring Circadian Amplitude

This blog is the spiritual sequel to our last blog post on ways of measuring sleep regularity. Unlike the last one, though, which was based on an excellent review article, this post is Olivia’s off-the-cuff (and extremely wonkish) thoughts on the topic of circadian amplitude. There’s a reason for a lack of formality, though, which […]

What we talk about when we talk about chronomedicine

I was reading this article on circadian variation in immune response a couple of weeks ago when I came across this quote, seemingly engineered in a lab to get my adrenaline pumping: “McKeating [says] that when she thinks back to the long line of failed vaccines in this field, she wonders whether timing may have […]